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Merck
CN

A6908

Acetopromazine maleate salt

≥98% (HPLC)

Synonym(s):

2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C19H22N2OS · C4H4O4
CAS Number:
3598-37-6
Molecular Weight:
442.53
EC Number:
222-748-9
UNSPSC Code:
12352200
MDL number:
MFCD00082473

Key Documents

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InChI key

FQRHOOHLUYHMGG-BTJKTKAUSA-N

InChI

1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES string

OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

H2O: >10 mg/mL

storage temp.

room temp

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Biochem/physiol Actions

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.
Atypical neuroleptic.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
047F0403

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P V Scrivani et al.
American journal of veterinary research, 59(10), 1227-1233 (1998-10-22)
To determine whether acepromazine (ACE) and butorphanol (BUT) combination can be used for restraint of dogs during positive-contrast upper gastrointestinal tract (UGIT) examination. 6 healthy dogs. In a randomized crossover design study, weekly UGIT examinations were performed on each dog
P M Taylor
Veterinary surgery : VS, 28(1), 77-82 (1999-02-20)
To investigate whether hypertonic saline infusion would prevent hypotension and pituitary-adrenocortical axis activation during halothane anesthesia after acepromazine premedication and thiopental induction in sheep. Randomized crossover study. Six Welsh Mountain ewes weighing 40+/-2 kg and aged 2 to 3 years.
Bobbi J Conner et al.
American journal of veterinary research, 73(5), 595-601 (2012-04-27)
To evaluate the effect of acepromazine maleate administered IV on platelet function assessed in healthy dogs by use of a modified thromboelastography assay. 6 healthy adult mixed-breed dogs. Dogs received each of 3 treatments (saline [0.9% NaCl] solution [1 to
Elisa Bortolami et al.
Veterinary anaesthesia and analgesia, 40(2), 181-193 (2012-06-27)
To investigate the safety, sedative and analgesic properties of methadone in combination with acepromazine prior to neutering in cats. Controlled clinical, block randomized, prospective, blinded study designed for regulatory purposes. 24 female and 21 male healthy cats. Cats received one
J M McGree et al.
Journal of veterinary pharmacology and therapeutics, 36(1), 31-42 (2013-01-16)
We describe the population pharmacokinetics of an acepromazine (ACP) metabolite (2-(1-hydroxyethyl)promazine) (HEPS) in horses for the estimation of likely detection times in plasma and urine. ACP (30 mg) was administered to 12 horses, and blood and urine samples were taken
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