A7230
Alinidine
≥98% (HPLC), solid
Synonym(s):
N-(2,6-Dichlorophenyl)-4,5-dihydro-N-2-propenyl-1H-imidazol-2-amine, ST-567
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About This Item
Empirical Formula (Hill Notation):
C12H13Cl2N3
CAS Number:
Molecular Weight:
270.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98% (HPLC)
form
solid
storage condition
under inert gas
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Clc1cccc(Cl)c1N(CC=C)C2=NCCN2
Biochem/physiol Actions
Alinidine is an HCN Channel blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.
Alinidine is an HCN channel blocker; Blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. Analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias).
Disclaimer
Air-sensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
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J L Challinor-Rogers et al.
Naunyn-Schmiedeberg's archives of pharmacology, 350(2), 158-166 (1994-08-01)
Alinidine, and eight derivatives, were synthesized and tested for their ability to antagonise the actions of the K+ channel opener cromakalim in rat thoracic aorta, and for their ability to induce bradycardia in rat isolated spontaneously beating right atria. Ring
J C Preiser et al.
Critical care medicine, 20(8), 1146-1151 (1992-08-01)
Alinidine is a recently developed antiarrhythmic medication that acts directly on the cardiac pacemaker cells to reduce heart rate (HR). At effective doses, alinidine might have cardiodepressant actions that could be hazardous in the presence of hemodynamic instability. On the
K Kodama et al.
Japanese journal of pharmacology, 60(2), 73-77 (1992-10-01)
We compared the antianginal effect of E4080, a novel bradycardiac agent with coronary vasodilating properties, with those of a bradycardiac agent and some coronary vasodilators in vasopressin-induced anginal model of guinea pigs. An i.v.-administration of vasopressin (0.2 IU/kg) produced an
M D Brown et al.
EXS, 61, 389-394 (1992-01-01)
Experiments were performed to test the hypothesis that increased stretch and/or tension of myocytes in the absence of changes in blood flow could induce capillary growth in the heart. Chronic treatment with either dobutamine (rabbits) or alinidine (rats) which increased
I Briggs et al.
Journal of cardiovascular pharmacology, 24(3), 380-387 (1994-09-01)
ZENECA ZD7288 (4-(N-ethyl-N-phenyl-amino)-1,2-dimethyl-6-(methylamino) pyrimidium chloride) is a novel compound which we compared with alinidine and UL-FS 49 (zatebradine) in guinea pig sinoatrial node (SAN) and papillary muscle preparations, using conventional microelectrode techniques. At low concentrations (1 x 10(-8)-1 x 10(-6)
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