A7480
N-Azidoacetylgalactosamine, Acetylated
Synonym(s):
GalNaz
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About This Item
Empirical Formula (Hill Notation):
C16H22N4O10
Molecular Weight:
430.37
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C16H22N4O10/c1-7(21)26-6-11-14(27-8(2)22)15(28-9(3)23)13(16(30-11)29-10(4)24)19-12(25)5-18-20-17/h11,13-16H,5-6H2,1-4H3,(H,19,25)/t11-,13-,14+,15-,16?/m1/s1
SMILES string
O=C(C)O[C@H]1[C@@H](COC(C)=O)OC(OC(C)=O)[C@H](NC(CN=[N+]=[N-])=O)[C@H]1OC(C)=O
InChI key
HGMISDAXLUIXKM-YJUJGKJLSA-N
storage temp.
2-8°C
Application
An unnatural azido sugar that can be introduced metabolically in model organisms and subsequently incorporates in glycan structures. The azide group will react with phosphines linked to agents for visualization or selective capture. To be used in conjunction with the FLAG®-Phosphine™ (GPHOS1) that is compatible with many additional FLAG tools for both applications.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Qiang Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(14), 7755-7763 (2020-03-21)
Methionine metabolism is critical for the maintenance of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) pluripotency. However, little is known about the regulation of the methionine cycle to sustain ESC pluripotency. Here, we show that adenosylhomocysteinase (AHCY)
Malin E V Johansson
PloS one, 7(7), e41009-e41009 (2012-07-21)
The enormous bacterial load and mechanical forces in colon create a special requirement for protection of the epithelium. In the distal colon, this problem is largely solved by separation of the bacteria from the epithelium by a firmly attached inner
Boya Deng et al.
Neoplasia (New York, N.Y.), 20(10), 1038-1044 (2018-09-13)
Alteration of protein O-glycosylation in various human cancers including breast cancer is well known, but molecular roles of their aberrant glycosylations on cancer have not been fully understood. We previously reported critical roles of polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6 or GalNAc-T6)
Anh Tuan Nguyen et al.
Cancer cell, 32(5), 639-653 (2017-11-15)
Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins. Here, we show that, in human and mouse liver cancers, initiation of O-glycosylation by the GALNT glycosyl-transferases increases and shifts
Julia E Maxson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 757-764 (2015-10-18)
Colony-stimulating factor 3 receptor (CSF3R) mutations have been identified in the majority of chronic neutrophilic leukemia (CNL) and a smaller percentage of atypical chronic myeloid leukemia (aCML) cases. Although CSF3R point mutations (e.g., T618I) are emerging as key players in
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