A8186
Arg-Lys-Arg-Ala-Arg-Lys-Glu
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C38H74N18O10
CAS Number:
Molecular Weight:
943.11
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(O)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
Inhibitor of cGMP-dependent protein kinase.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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E M Wexler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(7), 2342-2349 (1998-04-16)
Nitric oxide (NO) is thought to play an essential role in neuronal processing, but the downstream mechanisms of its action remain unclear. We report here that NO analogs reduce GABA-gated currents in cultured retinal amacrine cells via two distinct, but
Ji Ye Wei et al.
Brain research, 927(1), 42-54 (2002-01-30)
The mechanisms by which the intracellular messenger cGMP can modulate synaptic efficacy remain poorly understood. Here we report that cGMP, acting through cGMP-dependent protein kinase (PKG), has multiple rapid and reversible effects on synaptic transmission in slices and cultures of
J T San Agustin et al.
Cell motility and the cytoskeleton, 27(3), 206-218 (1994-01-01)
Ejaculated ram sperm were demembranated with Triton X-100, separated from the detergent-soluble matrix, and reactivated [San Agustin and Witman (1993): Cell Motil. Cytoskeleton 24:264-273]. The percent motility of models prepared from freshly washed sperm was comparable to that of the
D B Glass
The Biochemical journal, 213(1), 159-164 (1983-07-01)
The peptide Arg-Lys-Arg-Ala-Arg-Lys-Glu was synthesized and tested as an inhibitor of cyclic GMP-dependent protein kinase. This synthetic peptide is a non-phosphorylatable analogue of a substrate peptide corresponding to a phosphorylation site (serine-32) in histone H2B. The peptide was a competitive
Shannon M White et al.
Developmental cell, 49(3), 425-443 (2019-05-08)
Merlin/NF2 is a bona fide tumor suppressor whose mutations underlie inherited tumor syndrome neurofibromatosis type 2 (NF2), as well as various sporadic cancers including kidney cancer. Multiple Merlin/NF2 effector pathways including the Hippo-YAP/TAZ pathway have been identified. However, the molecular
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