A8724
ADP-ribosyltransferase C3 from Clostridium botulinum
Synonym(s):
Botulinum neurotoxin C3, C3 Exoenzyme, C3 Exotoxin, C3 Transferase
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Application
ADP-ribosyltransferase C3 from Clostridium botulinum may be used to study cellular signaling and G protein expression .
Biochem/physiol Actions
ADP-ribosyltransferase C3 from Clostridium botulinum ribosylates rho in eukaryotes in the presence of NAD. The ADP-ribosylating exoenzyme forms a single major 25 kDA (approx.) band with SDS electrophoresis. The enzyme labels 21-24 kDa proteins in tissues such as the human platelet membranes.
Ribosylates rho in eukaryotes in the presence of NAD.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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K Aktories et al.
European journal of biochemistry, 172(2), 445-450 (1988-03-01)
A novel ADP-ribosyltransferase C3 was purified to homogeneity from filtrates of certain strains of Clostridium botulinum type C by ammonium sulfate precipitation, gel filtration, ion-exchange chromatography and heat treatment. The molecular mass of botulinum ADP-ribosyltransferase C3 was found to be
Y Ohoka et al.
Journal of biochemistry, 109(3), 428-435 (1991-03-01)
A GTP-binding protein with an Mr of 24,000 was purified from a cholate extract of bovine brain membranes in addition to the previously reported alpha beta gamma-trimeric GTP-binding proteins (G proteins). Partial amino acid sequence analysis of the purified 24-kDa
Qi Jia et al.
Plant molecular biology, 82(4-5), 339-351 (2013-04-30)
Besides the KU-dependent classical non-homologous end-joining (C-NHEJ) pathway, an alternative NHEJ pathway first identified in mammalian systems, which is often called the back-up NHEJ (B-NHEJ) pathway, was also found in plants. In mammalian systems PARP was found to be one
Jonathan Ledermann et al.
The Lancet. Oncology, 15(8), 852-861 (2014-06-03)
Maintenance monotherapy with the PARP inhibitor olaparib significantly prolonged progression-free survival (PFS) versus placebo in patients with platinum-sensitive recurrent serous ovarian cancer. We aimed to explore the hypothesis that olaparib is most likely to benefit patients with a BRCA mutation.
Sugiko Watanabe et al.
Nature structural & molecular biology, 20(12), 1425-1433 (2013-11-19)
Chromatin ubiquitylation flanking DNA double-strand breaks (DSBs), mediated by RNF8 and RNF168 ubiquitin ligases, orchestrates a two-branch pathway, recruiting repair factors 53BP1 or the RAP80-BRCA1 complex. We report that human demethylase JMJD1C regulates the RAP80-BRCA1 branch of this DNA-damage response
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