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Merck
CN

A8802

Sigma-Aldrich

Antide

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C82H108ClN17O14
CAS Number:
112568-12-4
Molecular Weight:
1591.29
MDL number:
MFCD00133104
UNSPSC Code:
12352200
PubChem Substance ID:
24891367
NACRES:
NA.32

Key Documents

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Assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(CCCCNC(=O)c1cccnc1)NC(=O)C(CCCCNC(=O)c2cccnc2)NC(=O)C(CO)NC(=O)C(Cc3cccnc3)NC(=O)C(Cc4ccc(Cl)cc4)NC(=O)C(Cc5ccc6ccccc6c5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O

InChI

1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)

InChI key

QRYFGTULTGLGHU-UHFFFAOYSA-N

Gene Information

rat ... Gnrhr(81668)

Amino Acid Sequence

Ac-Ala-Phe-Ala-Ser-Lys-Lys-Leu-Lys-Pro-Ala-NH2

Application

Antide has been used as a gonadotropin-releasing hormone (GnRH) antagonist to study its effects on regulating apoptosis in a bovine granulosa cell line (BGC-1) and to determine its GnRH effects on cleavage rates of bovine oocytes in vitro.

Biochem/physiol Actions

Antide is a luteinizing hormone-releasing hormone (LHRH) antagonist with high anti-ovulatory and negligible histamine release activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC2014
BCBJ6857V
BCBJ6857
BCBG9289V
BCBG9289

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Sarah E A McConnell et al.
Hormones and behavior, 61(4), 479-486 (2012-01-24)
Attempts to determine the influence of testicular hormones on learning and memory in males have yielded contradictory results. The present studies examined whether testicular hormones are important for maximal levels of spatial memory in young adult male rats. To minimize
L Simon et al.
International journal of andrology, 35(3), 364-376 (2011-12-14)
We previously reported that oestrogen exposure in neonatal rats induced permanent infertility and malformed penis characterized by fat accumulation, which replaced most of the smooth muscle cells and cavernous spaces in the body of the penis, structures essential for erection.
Ann R Finch et al.
Molecular endocrinology (Baltimore, Md.), 24(2), 423-435 (2009-12-17)
Gonadotropin-releasing hormone acts via cell surface receptors but most human (h) GnRH receptors (GnRHRs) are intracellular. A membrane-permeant nonpeptide antagonist [(2S)-2-[5-[2-(2-axabicyclo[2.2.2]oct-2-yl)-1,1-dimethy-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-N-(2-pyridin-4-ylethyl)propan-1-amine (IN3)] increases hGnRHR expression at the surface, apparently by facilitating its exit from the endoplasmic reticulum. Here we have
Sarah Dünnhaupt et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(3), 477-485 (2012-05-01)
The aim of the present study was the development and evaluation in vitro as well as in vivo of an oral delivery system based on a novel type of thiolated chitosan, so-called S-protected thiolated chitosan, for the peptide drug antide.
Marcos García-Juárez et al.
Neuropeptides, 45(1), 63-67 (2010-11-30)
Dose response curves for leptin facilitation of estrous behavior (lordosis and proceptivity) were made by infusing the peptide into the lateral ventricle (icv) of ovariectomized (ovx), ad libitum-fed rats injected 40h previously with 5μg of estradiol benzoate. Leptin doses of
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