A8855
Monoclonal Anti-Alzheimer′s Disease Tau antibody produced in mouse
clone DC11, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-AD Tau
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
DC11, monoclonal
form
buffered aqueous solution
mol wt
antigen 20-68 kDa
species reactivity
human
technique(s)
immunohistochemistry: 1:1,000, indirect immunofluorescence: 1:1,000, western blot: 1:500 using Alzheimer´s diseased brain tissue
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... MAPT(4137)
General description
Tau is an axonal protein that promotes microtubule assembly and stabilizes neuronal microtubules. Under pathological conditions, Tau can get hyperphosphorylated and form aberrant aggregates similar to those found in Alzheimer′s disease.
The antibody recognizes only human Alzheimer´s tau that is conformationally different from normal tau and shows no cross-reactivity with tau from age-matched control brains or with six recombinant tau isoforms, MAPs, or tubulin.
Immunogen
Alzheimer´s tau isolated from AD brain.
Application
Autopsied human brains were formalin-fixed and paraffin-embedded then cut into 10 um sections for immunohistochemistry using monoclonal mouse anti-Alzheimer′s Disease Tau antibody at a dilution of 1:1000.
Mouse Monoclonal Anti-Alzheimer′s Disease Tau antibody has been used for immunohistochemical applications. The antibody can also be used for indirect immunofluorescence (1:1,000) and western blot (1:500) applications.
Physical form
Solution in DMEM (without sodium pyruvate and sodium bicarbonate) containing 0.1% thimerosal as a preservative.
Disclaimer
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Warning
hcodes
pcodes
Hazard Classifications
STOT RE 2
target_organs
Kidney
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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T Uchihara et al.
Stroke, 26(11), 2145-2148 (1995-11-01)
Tau-like immunoreactivity is known to develop in neurons under some experimental conditions simulating ischemia. The purpose of this study is to investigate the expression of tau-like immunoreactivity in the human brain after ischemic insult. A series of autopsied human brains
Yasuyuki Honjo et al.
Journal of Alzheimer's disease : JAD, 38(3), 601-609 (2013-09-17)
Amyloid plaques and neurofibrillary tangles (NFTs) are the major pathological characteristics of Alzheimer's disease (AD). NFTs are composed of tubular filaments and paired helical filaments containing polymerized hyperphosphorylated tau protein. Another feature of AD is excessive generation of nitric oxide
Lubica Vechterova et al.
Neuroreport, 14(1), 87-91 (2003-01-25)
Using tau protein extracts from Alzheimer's disease (AD) brain tissue, we generated a monoclonal antibody (mAb DC11) which decorated neurofibrillary pathology in brain derived from AD patients on immunohistochemistry, and which lacked reactivity with healthy brain tissue. The same pattern
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