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Merck
CN

A8855

Sigma-Aldrich

Monoclonal Anti-Alzheimer′s Disease Tau antibody produced in mouse

clone DC11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-AD Tau

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About This Item

MDL number:
MFCD00164745
UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

clone

DC11, monoclonal

form

buffered aqueous solution

mol wt

antigen 20-68 kDa

species reactivity

human

technique(s)

immunohistochemistry: 1:1,000
indirect immunofluorescence: 1:1,000
western blot: 1:500 using Alzheimer´s diseased brain tissue

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Tau is an axonal protein that promotes microtubule assembly and stabilizes neuronal microtubules. Under pathological conditions, Tau can get hyperphosphorylated and form aberrant aggregates similar to those found in Alzheimer′s disease.
The antibody recognizes only human Alzheimer´s tau that is conformationally different from normal tau and shows no cross-reactivity with tau from age-matched control brains or with six recombinant tau isoforms, MAPs, or tubulin.

Immunogen

Alzheimer´s tau isolated from AD brain.

Application

Autopsied human brains were formalin-fixed and paraffin-embedded then cut into 10 um sections for immunohistochemistry using monoclonal mouse anti-Alzheimer′s Disease Tau antibody at a dilution of 1:1000.
Mouse Monoclonal Anti-Alzheimer′s Disease Tau antibody has been used for immunohistochemical applications. The antibody can also be used for indirect immunofluorescence (1:1,000) and western blot (1:500) applications.

Physical form

Solution in DMEM (without sodium pyruvate and sodium bicarbonate) containing 0.1% thimerosal as a preservative.

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H373

Precautionary Statements

P260 - P314 - P501

Hazard Classifications

STOT RE 2

Target Organs

Kidney

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
099K1517
058K1416
028K1643
126K1026

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