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A8949

Sigma-Aldrich

L-Aspartic acid

BioXtra, ≥99% (HPLC)

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Synonym(s):
(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid
Linear Formula:
HO2CCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
133.10
Beilstein:
1723530
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product line

BioXtra

Quality Level

Assay

≥99% (HPLC)

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 0.5 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

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Biochem/physiol Actions

L-Aspartic acid is a natural proteinogenic amino acid that may be used in the formulation of cell culture media and in protein and polypeptide synthesis systems and procedures. L-Aspartic acid, an NMDA receptor agonist and non-specific glutamate receptor agonist, is used to differentiate and study the mechanisms of NMDA receptors.
Principal neurotransmitter for fast synaptic excitation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Irena Roci et al.
Cell reports, 26(7), 1691-1700 (2019-02-14)
Alterations in cell-cycle regulation and cellular metabolism are associated with cancer transformation, and enzymes active in the committed cell-cycle phase may represent vulnerabilities of cancer cells. Here, we map metabolic events in the G1 and SG2M phases by combining cell
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Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells, we traced the developmental stages
Ann-Louise Johansson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8912-8917 (2013-05-16)
Proton transfer across biological membranes underpins central processes in biological systems, such as energy conservation and transport of ions and molecules. In the membrane proteins involved in these processes, proton transfer takes place through specific pathways connecting the two sides
Guus B Erkens et al.
Nature, 502(7469), 119-123 (2013-10-05)
Excitatory amino acid transporters (EAATs) are secondary transport proteins that mediate the uptake of glutamate and other amino acids. EAATs fulfil an important role in neuronal signal transmission by clearing the excitatory neurotransmitters from the synaptic cleft after depolarization of
Manuel Neeb et al.
Journal of medicinal chemistry, 57(13), 5554-5565 (2014-06-24)
Drug molecules should remain uncharged while traveling through the body and crossing membranes and should only adopt charged state upon protein binding, particularly if charge-assisted interactions can be established in deeply buried binding pockets. Such strategy requires careful pKa design

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