A8950
ADP-ribosylcyclase
lyophilized powder, 1,000-3,000 units/mg protein (BCA)
Synonym(s):
Adenosine diphosphoribose cyclase from Aplysia californica
form
lyophilized powder
specific activity
1,000-3,000 units/mg protein (BCA)
composition
Protein, <10%
packaging
vial of ~100 μg protein
storage temp.
−20°C
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Biochem/physiol Actions
Intracellular calcium regulator; synthetic enzyme for production of cyclic ADP-ribose
Physical form
Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol
Other Notes
One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 min at pH 7.0 and 25°C.
Regulatory Information
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H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
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