A9052
Atrial Natriuretic Peptide chicken
≥95% (HPLC)
Synonym(s):
ANF 1-29
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About This Item
Empirical Formula (Hill Notation):
C124H211N47O40S5
CAS Number:
Molecular Weight:
3160.62
MDL number:
UNSPSC Code:
12352200
Assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
chicken ... LOC395765(395765)
Amino Acid Sequence
Met-Met-Arg-Asp-Ser-Gly-Cys-Phe-Gly-Arg-Arg-Ile-Asp-Arg-Ile-Gly-Ser-Leu-Ser-Gly-Met-Gly-Cys-Asn-Gly-Ser-Arg-Lys-Asn [Disulfide bridge: 7–23]
Biochem/physiol Actions
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
Preparation Note
Originally isolated from atrium.
Analysis Note
Has diuretic-natriuretic and hypotensive activity similar to mammalian ANF.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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A Miyata et al.
Biochemical and biophysical research communications, 155(3), 1330-1337 (1988-09-30)
Morphological and pharmacological observations have suggested that chicken atrial natriuretic peptide (ANP) is different from mammalian ANP. The present survey for the as yet unidentified ANP in chicken heart was performed by monitoring the relaxant effect on chick rectum. From
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