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A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

Synonym(s):

Adenosine diphosphoribose cyclase from Aplysia californica

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About This Item

CAS Number:
135622-82-1
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00212894
Specific activity:
1000-3000 units/mg protein
Assay:
≥80 μ protein/vial (BCA)
Biological source:
(Aplysia californica)
Concentration:
≤10% (BCA method)
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biological source

(Aplysia californica)

Quality Segment

assay

≥80 μ protein/vial (BCA)

form

lyophilized powder

specific activity

1000-3000 units/mg protein

composition

Protein, ≤10%

packaging

vial of ≥80 μg protein

storage condition

dry at room temperature

concentration

≤10% (BCA method)

suitability

suitable for enzyme test

application(s)

genomic analysis

storage temp.

−20°C

Application

ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Physical form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Other Notes

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Codes

H334

Precautionary Statements

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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