A9106
ADP-ribosylcyclase
1000-3000 units/mg protein
Synonym(s):
Adenosine diphosphoribose cyclase from Aplysia californica
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About This Item
Specific activity:
1000-3000 units/mg protein
Assay:
≥80 μ protein/vial (BCA)
Biological source:
(Aplysia californica)
Concentration:
≤10% (BCA method)
biological source
(Aplysia californica)
Quality Segment
assay
≥80 μ protein/vial (BCA)
form
lyophilized powder
specific activity
1000-3000 units/mg protein
composition
Protein, ≤10%
packaging
vial of ≥80 μg protein
storage condition
dry at room temperature
concentration
≤10% (BCA method)
suitability
suitable for enzyme test
application(s)
genomic analysis
storage temp.
−20°C
Application
ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .
Biochem/physiol Actions
ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .
Physical form
Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol
Other Notes
One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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