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A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

Synonym(s):

Adenosine diphosphoribose cyclase from Aplysia californica

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About This Item

CAS Number:
135622-82-1
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00212894

Key Documents

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Product Name

ADP-ribosylcyclase, 1000-3000 units/mg protein

biological source

(Aplysia californica)

assay

≥80 μ protein/vial (BCA)

form

lyophilized powder

specific activity

1000-3000 units/mg protein

composition

Protein, ≤10%

packaging

vial of ≥80 μg protein

storage condition

dry at room temperature

concentration

≤10% (BCA method)

suitability

suitable for enzyme test

application(s)

genomic analysis

storage temp.

−20°C

Quality Level

200

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Application

ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Other Notes

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.

Physical form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

动植物源性产品
低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
0000440760
0000440760
SLCD5460
SLBM9693V
098K7430

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Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
Nicholas D Peterson et al.
eLife, 11 (2022-02-01)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain protein
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