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Merck
CN

A9420

6-Acetyl-7-deacetylforskolin

from Coleus forskohlii, ≥98%

Synonym(s):

6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one, Isoforskolin

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About This Item

Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
Molecular Weight:
410.50
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
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biological source

Coleus forskohlii

assay

≥98%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

storage temp.

−20°C

SMILES string

CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1

InChI key

CLOQVZCSBYBUPB-VDCUXWMXSA-N

Biochem/physiol Actions

Antihypertensive with positive inotropic and adenyl cyclase activating properties

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Bhat, S.V., et al.
Tetrahedron Letters, 1669-1669 (1977)
S V Bhat et al.
Journal of medicinal chemistry, 26(4), 486-492 (1983-04-01)
Four naturally occurring analogues of forskolin were isolated. Forty-nine semisynthetic derivatives were prepared, incorporating structural alterations at the 1-, 6-, 7-, 9-, 11-, and 14/15-positions. Blood pressure lowering properties of 53 compounds were assessed in anesthetized normotensive cats and of

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