A9436
N-Acetyl-β-Asp-Glu
≥98% (TLC), suitable for ligand binding assays
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About This Item
Empirical Formula (Hill Notation):
C11H16N2O8
CAS Number:
Molecular Weight:
304.25
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
N-Acetyl-β-Asp-Glu,
SMILES string
CC(=O)NC(CC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O
InChI key
GUCKKCMJTSNWCU-UHFFFAOYSA-N
InChI
1S/C11H16N2O8/c1-5(14)12-7(11(20)21)4-8(15)13-6(10(18)19)2-3-9(16)17/h6-7H,2-4H2,1H3,(H,12,14)(H,13,15)(H,16,17)(H,18,19)(H,20,21)
assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to faint yellow
mp
115-116 °C
storage temp.
−20°C
Biochem/physiol Actions
N-Acetyl-β-Asp-Glu (βNAAG) is used as a substrate/inhibitor to identify and characterize glutamate carboxypeptidase(s). βNAAG is often used together witn N-Acetyl-Asp-Glu (NAAG), a neuropeptide, to differentiate the activity of glutamate carboxypeptidase activity and function in vivo.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Artem I Malomouzh et al.
Journal of neurochemistry, 94(1), 257-267 (2005-06-15)
N-Acetylaspartylglutamate (NAAG), known to be present in rat motor neurons, may participate in neuronal modulation of non-quantal secretion of acetylcholine (ACh) from motor nerve terminals. Non-quantal release of ACh was estimated by the amplitude of the endplate membrane hyperpolarization (H-effect)
François Collard et al.
The Journal of biological chemistry, 286(44), 38220-38230 (2011-09-13)
β-Citrylglutamate (BCG), a compound present in adult testis and in the CNS during the pre- and perinatal periods is synthesized by an intracellular enzyme encoded by the RIMKLB gene and hydrolyzed by an as yet unidentified ectoenzyme. To identify β-citrylglutamate
Seiichi Sakatani et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(43), 10928-10936 (2008-10-24)
S100B is the principal calcium-binding protein of astrocytes and known to be secreted to extracellular space. Although secreted S100B has been reported to promote neurite extension and cell survival via its receptor [receptor for advanced glycation end products (RAGE)], effects
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