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CN

A9451

Aristolochic acid I sodium salt

powder, ≥97%

Synonym(s):

Aristolochic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C17H10NNaO7
CAS Number:
10190-99-5
Molecular Weight:
363.25
NACRES:
NA.77
PubChem Substance ID:
24891454
UNSPSC Code:
12352202
EC Number:
233-463-4
MDL number:
MFCD00210760

Key Documents

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Product Name

Aristolochic acid I sodium salt, powder, ≥97%

InChI key

BQVOPWJSBBMGBR-UHFFFAOYSA-M

InChI

1S/C17H11NO7.Na/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13;/h2-6H,7H2,1H3,(H,19,20);/q;+1/p-1

SMILES string

[Na+].COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C([O-])=O

assay

≥97%

form

powder

solubility

H2O: 50 mg/mL

Quality Level

200

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Biochem/physiol Actions

Component of some Chinese herbal medicines, and responsible for their nephrotoxicity. Prodrug activated by reduction of the nitro group to an amine, which forms cytotoxic DNA adducts.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7498V
WXBF5849V
WXBF3627V
WXBF0804V
WXBD8085V

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Huan Lu et al.
Theranostics, 10(10), 4323-4333 (2020-04-16)
Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced
Marika Manolopoulou et al.
American journal of physiology. Renal physiology, 316(5), F847-F855 (2019-02-14)
Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and proximal tubule markers that may be
Khai Gene Leong et al.
Toxins, 13(10) (2021-10-23)
The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA is taken up
Xiaoyan Wang et al.
Cell death & disease, 11(8), 620-620 (2020-08-17)
Acute kidney injury (AKI) has a critical role in the development of chronic kidney disease (CKD). Building on our previous findings, we explored the role of miR-382 in facilitating the transition of AKI to CKD using the Aristolochic acid (AA)
Sang Hoon Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(18), 8440-8445 (2010-04-21)
Mammalian sweet, bitter, and umami taste is mediated by a single transduction pathway that includes a phospholipase C (PLC)beta and one cation channel, TRPM5. However, in insects such as the fruit fly, Drosophila melanogaster, it is unclear whether different tastants
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