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A9856

Monoclonal Anti-AP-2β antibody produced in mouse

Name: Monoclonal Anti-AP-2β antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone AP2b 1F3/8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-AP-2B, Anti-AP2-B

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About This Item

UNSPSC Code:

12352203

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AP2b 1F3/8, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect ELISA: suitable, western blot: 5-10 μg/mL using U87total cell extract

isotype

IgG2a

UniProt accession no.

Q92481

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TFAP2B(7021)

General description

Adaptor protein-2 (AP2) is a key constituent of clathrin-coated vesicles that mediates the endocytosis of cell membrane components such as G protein-coupled receptors (GPCRs). AP2 is a heterotetramer that consists of α, β, μ and σ subunits which bind to tyrosine- and dileucine-based motifs on membrane-associated cargo proteins.
Mouse Monoclonal Anti-AP-2β antibody recognizes human AP-2β.

Immunogen

truncated human AP-2β recombinant protein.

Application

Mouse Monoclonal Anti-AP-2beta antibody can be used for western blot (5-10 μg/ml) and indirect ELISA.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

098K4773

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The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila.

Tomasz Szul et al.

Cellular logistics, 1(2), 69-76 (2011-06-21)

Surface delivery of proteins involved in cell-cell and cell-matrix interactions in cultured mammalian cells requires the GBF1 guanine nucleotide exchange factor. However, the role of GBF1 in delivery of adhesion proteins during organogenesis in intact animals has not been characterized.

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

M Andrew Nesbit et al.

Nature genetics, 45(1), 93-97 (2012-12-12)

Adaptor protein-2 (AP2), a central component of clathrin-coated vesicles (CCVs), is pivotal in clathrin-mediated endocytosis, which internalizes plasma membrane constituents such as G protein-coupled receptors (GPCRs). AP2, a heterotetramer of α, β, μ and σ subunits, links clathrin to vesicle

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