A9900
[Sar1, Thr8]-Angiotensin II acetate salt hydrate
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C44H69N13O11 · xC2H4O2 · yH2O
Molecular Weight:
956.10 (anhydrous free base basis)
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
assay
≥97% (HPLC)
form
solid
storage temp.
−20°C
Quality Level
Gene Information
human ... AGTR1(185), AGTR2(186), AGTRAP(57085)
mouse ... AGTR1(11607), AGTR1B(11608), AGTR2(11609), AGTRAP(11610)
rat ... AGTR1(24180), AGTR1B(81638), AGTR2(24182), AGTRAP(298646)
Biochem/physiol Actions
Potent, long-acting antagonist of angiotensin II.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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R K Tuominen et al.
Journal of neurochemistry, 56(4), 1292-1298 (1991-04-01)
Previous studies from our laboratory suggest that protein kinase C (PKC) is involved in the angiotensin II (AII)-induced increase in the expression of genes encoding proenkephalin and catecholamine biosynthesizing enzymes in primary cultured bovine adrenal medullary (BAM) cells. The purpose
Y H Ku et al.
Peptides, 20(2), 171-176 (1999-07-28)
In urethane-anesthetized rats, microinjection of angiotensin II (AII) into either the subfornical organ (SFO), nucleus paraventricularis (NPV), or rostral ventrolateral medulla (RVL), respectively, all induced pressor responses, but the heart rate remained unchanged. Preinjection of [Sar1, Thr8]-angiotensin II (ST-AII, an
S Ito et al.
The American journal of physiology, 270(6 Pt 2), R1317-R1323 (1996-06-01)
The rostral ventrolateral medulla (RVLM) plays a primary role in the tonic and phasic control of arterial blood pressure. Stimulation of angiotensin receptors in this region appears to contribute to the tonic excitatory drive of RVLM neurons involved in the
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