AC-0365A
Claudin-7 (EP399) Rabbit Monoclonal Primary Antibody
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
monoclonal
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
Application:
IHC (p)
Citations:
-
biological source
rabbit
antibody form
Ig fraction of antiserum
clone
monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
Quality Level
General description
The claudin family of epithelial tight junction proteins that play critical roles for cell-cell adhesion and maintenance of cellular polarity. Claudin members are expressed in a tissue specific manner; claudin-7 expression is localized to the distal nephron epithelium. Claudin-7 has been extensively studied in renal cell carcinoma (RCC) subtypes. By immunohistochemical (IHC) analysis, membranous claudin-7 expression was detected in 67% of chromophobe RCC, compared with 0% of clear cell RCCs, 28% of papillary RCCs, and 23% oncocytomas. Claudin-7 expression may provide clinical utility in the differential diagnosis of chromophobe RCC and oncocytoma. While both chromophobe RCC and oncocytoma are derived from intercalated cells of the cortical collecting duct, oncocytomas are typically benign lesions whereas chromophobe RCCs are potentially aggressive malignancies. These RCC subtypes can be difficult to differentiate by morphology alone. Hornsby and colleagues examined claudin-7 IHC and reported 71% and 73% positive and negative predictive values for the differential diagnosis of chromophobe RCC from oncocytoma.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
监管及禁止进口产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service