AP5
Aprotinin−Agarose
column volume
2.5 mL
storage temp.
2-8°C
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Other Notes
One trypsin inhibitor unit (TIU) will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmole of Nα-benzoyl-DL-arginine p-nitroanilide (BAPNA) per min at pH 7.8 at 25°C.
Prepacked columns
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Ziv Beckerman et al.
The Journal of thoracic and cardiovascular surgery, 145(1), 243-248 (2012-10-18)
Cardiac surgery patients are treated with antifibrinolytic agents to reduce intra- and postoperative bleeding. Until 2007, lysine analogues (aminocaproic acid and tranexamic acid) and serine protease inhibitors (aprotinin) were recommended. In 2008, the U.S. Food and Drug Administration prohibited aprotinin
A F L Later et al.
Cytokine, 61(2), 438-444 (2012-11-29)
Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used.
Bernhard Glotzbach et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 114-120 (2013-01-01)
In recent decades, several canonical serine protease inhibitor families have been classified and characterized. In contrast to most trypsin inhibitors, those from garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) do not share sequence similarity and have been proposed
Zbigniew Dauter
Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 2-4 (2013-01-01)
To uniquely describe a crystal structure, it is sufficient to specify the crystal unit cell and symmetry, and describe the unique structural motif which is repeated by the space-group symmetry throughout the whole crystal. It is somewhat arbitrary how such
Alexander F L Later et al.
The Journal of thoracic and cardiovascular surgery, 145(6), 1611-1616 (2013-01-22)
Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved. Whole-blood
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