PrEST Antigen XRCC4

Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.

Suitable as a blocking agent using corresponding antibodies.

X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)

Solution in 1 M urea-PBS, pH 7.4

The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.

Corresponding Antibody HPA006801.

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