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APREST72768

Sigma-Aldrich

PrEST Antigen CHRM1

Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution

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About This Item

UNSPSC Code:
12352202

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recombinant

expressed in E. coli

Assay

>80% (SDS-PAGE)

form

buffered aqueous solution

mol wt

predicted mol wt 32 kDa

purified by

immobilized metal affinity chromatography (IMAC)

concentration

≥0.5 mg/mL

immunogen sequence

SETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE

Ensembl | human accession no.

ENSG00000168539

UniProt accession no.

P11229

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CHRM1(1128)

General description

Recombinant protein fragment of Human CHRM1 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. Cholinergic receptor, muscarinic 1 (CHRM1) is also known as muscarinic acetylcholine receptor M1 (mAChRs). It encoded by gene CHRM1 located on human chromosome 11q12.3. Cholinergic receptor, muscarinic 1 (CHRM1) belongs to G protein-coupled receptors and comprises of 5 subtypes: M1 to M5.

Application

Suitable as a blocking agent using corresponding antibodies.

Biochem/physiol Actions

CHRM1 is activated by acetylcholine and it regulates multitude of physiological processes of the central and peripheral nervous system. It is also associated with learning, cognition and memory. CHRM1 is allosterically regulated and is a prime target for drug design in disorders of central nervous system. CHRM1 receptor modulation improves cognitive function. Elevated levels of CHRM1- acetylcholine complex is observed in patients with Alzheimer′s disease. Single polynucleotide polymorphisms in CHRM1 is observed in patients with schizophrenia. Mutations in the CHRM1 gene locus is associated with facial impairment and developmental delay.

Physical form

Solution in 1 M urea-PBS, pH 7.4

Preparation Note

The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.

Other Notes

Corresponding Antibody HPA014101.

Legal Information

Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning
Shirey JK, et al.
The Journal of Neuroscience, 29(45), 14271-14286 (2009)
The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia
Cropley VL, et al.
Psychiatry research. Neuroimaging, 234(2), 182-187 (2015)
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Wess J, et al.
Nature Reviews Drug Discovery, 6(9), 721-721 (2007)
Toshiyuki Yamamoto et al.
Molecular cytogenetics, 6(1), 15-15 (2013-04-05)
Triplication is a rare chromosomal anomaly. We identified a de novo triplication of 11q12.3 in a patient with developmental delay, distinctive facial features, and others. In the present study, we discuss the mechanism of triplications that are not embedded within
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
Thal DM, et al.
Nature, 531(7594), 335-335 (2016)
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