APREST76958
PrEST Antigen MATN1
Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution
Synonym(s):
CMP, CRTM
recombinant
expressed in E. coli
Assay
>80% (SDS-PAGE)
form
buffered aqueous solution
mol wt
predicted mol wt 26 kDa
purified by
immobilized metal affinity chromatography (IMAC)
concentration
≥0.5 mg/mL
immunogen sequence
REIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV
Ensembl | human accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MATN1(4146)
General description
Matrilin 1 (MATN1) is also called the cartilage matrix protein (CMP) and is the major matrix component of cartilage. The gene encoding MATN1 is mapped to human chromosome 1p35.2. Matrilin 1 (MATN1) encodes a protein of 52,000 Da and exists as trimer. It has von Willebrand factor A domain. It is a glycoprotein and interacts with cartilage collagen fibrils.
Application
Suitable as a blocking agent using corresponding antibodies.
Biochem/physiol Actions
Autoantibodies to Matrilin 1 (MATN1) is implicated in patients with autoimmune disorder, polychondritis. MATN1 inhibits new capillary and blood vessel formation and could be used for treating diseases associated with improper neovascularization. Mutations in MATN1 gene impacts the assembly process of collagen. MATN1 gene polymorphisms result in spine deformity and is associated with familial idiopathic scoliosis
Physical form
Solution in 1 M urea-PBS, pH 7.4
Preparation Note
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Other Notes
Corresponding Antibody HPA028580.
Legal Information
Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis
Hansson A, et al.
Arthritis and Rheumatism, 44(10), 2402-2412 (2001)
The matrilins-adaptor proteins in the extracellular matrix
Wagener R, et al.
Febs Letters, 579(15), 3323-3329 (2005)
The matrilins: a novel family of oligomeric extracellular matrix proteins
Deak F, et al.
Matrix Biology, 18(1), 55-64 (1999)
Matrilins: structure, expression and function
Segat D, et al.
Osteoarthritis and Cartilage, 9, S29-S35 (2001)
Evidence of a linkage between matrilin-1 gene (MATN1) and idiopathic scoliosis
Montanaro L, et al.
Scoliosis and Spinal Disorders, 1(1), 21-21 (2006)
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