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Merck
CN

AV100935

Anti-HOXC6 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CP25, Anti-HHO.C8, Anti-HOX3, Anti-HOX3C, Anti-Homeobox C6

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

27 kDa

species reactivity

mouse, rat, human, bovine, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_004494

UniProt accession no.

P09630

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HOXC6(3223)

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Immunogen

Synthetic peptide directed towards the C terminal region of human HOXC6

Application

Anti-HOXC6 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5 μg/ml.

Biochem/physiol Actions

HOXC6 belongs to the homeoprotein family of transcription factors that regulate morphogenesis and differentiation during embryonic development. Extensive crosstalk between HOXC6 and Wnt, Notch and PI3Kpathways has been observed in prostate cancer progression. HOXC6 also modulates the expression of Bcl-2 and regulates anti-apoptotic pathway in human head and neck squamous cell carcinoma.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: KIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
QC21478

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Carlos S Moreno
The American journal of pathology, 176(2), 518-527 (2009-12-19)
The transforming growth factor beta, Hedgehog, Notch, and Wnt signaling pathways all play critical roles in the development and progression of prostate cancer. It is becoming increasingly apparent that these pathways may intersect with developmentally important transcription factors such as
Sung-Min Moon et al.
The Journal of biological chemistry, 287(42), 35678-35688 (2012-08-17)
Homeobox C6 (HOXC6) genes belong to the homeoprotein family of transcription factors, which play an important role in morphogenesis and cellular differentiation during embryonic development. The aim of this study was to explore the role of HOXC6 in the regulation

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