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Merck
CN

AV31513

Anti-RIPK3 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-RIP3, Anti-RIP3beta, Anti-RIP3gamma, Anti-Receptor-interacting serine-threonine kinase 3

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD03097232

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

57 kDa

species reactivity

horse, rat, bovine, canine, pig, human, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_006862

UniProt accession no.

Q9Y572

storage temp.

−20°C

Gene Information

human ... RIPK3(11035)

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General description

Rabbit polyclonal anti-RIPK3 antibody reacts with mouse, bovine, canine, and human receptor-interacting serine-threonine kinase 3 kinases.
Receptor-interacting serine-threonine kinase 3 (RIPK3, RIP3β, RIP3gamma) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and it is involved in the regulation of (tumor necrosis factor (TNF)-related apoptosis inducing ligand) TRAIL-induced apoptosis.

Immunogen

The immunogen for anti-RIPK3 antibody: synthetic peptide derected towards the N terminal of human RIPK3

Application

Anti-RIPK3 antibody has been used for the studying the role of RIPK3 in necroptosis. The antibody can be used for western blot (1.25μg/ml) and IHC (4-8μg/ml, using paraffin-embedded tissues) applications.
Rabbit polyclonal anti-RIPK3 antibody is used to tag receptor-interacting serine-threonine kinase 3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of receptor-interacting serine-threonine kinase 3 apoptosis pathways.

Physical form

Lyophilized from PBS buffer with 2% sucrose

Other Notes

Synthetic peptide located within the following region: GGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC11984

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Linde Duprez et al.
The Journal of biological chemistry, 287(18), 14863-14872 (2012-03-01)
Receptor-interacting protein kinase 1 (RIPK1) is an important component of the tumor necrosis factor receptor 1 (TNFR1) signaling pathway. Depending on the cell type and conditions, RIPK1 mediates MAPK and NF-κB activation as well as cell death. Using a mutant

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