AV32753
Anti-OLIG2 Antibody
rabbit polyclonal
Synonym(s):
Anti-Oligodendrocyte lineage transcription factor 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Product Name
Anti-OLIG2 (AB1) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
32 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OLIG2(10215)
Application
Rabbit Anti-OLIG2 (AB1) antibody can be used for western blot applications at a concentration of 0.5 μg/ml.
Rabbit polyclonal anti-OLIG2 antibody is used to tag oligodendrocyte lineage transcription factor 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of oligodendrocyte lineage transcription factor 2 in ventral neuroectodermal progenitor cell fate and as a diffuse glioma marker protein.
Biochem/physiol Actions
OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia due to a chromosomal translocation t(14;21)(q11.2;q22). OLIG2 might play a role in learning deficits associated with Down syndrome.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Oligodendrocyte lineage transcription factor 2 (OLIG2), a basic helix-loop-helix transcription factor, is an essential regulator of ventral neuroectodermal progenitor cell fate and is required for oligodendrocyte and motor neuron development. OLIG2 is a universal marker of diffuse gliomas including oligodendroglioma, astrocytoma, glioblastoma, and mixed glioma.
Rabbit polyclonal anti-OLIG2 antibody reacts with chicken, human, and mouse oligodendrocyte lineage transcription factor 2 transcription factors.
Immunogen
Synthetic peptide directed towards the C-terminal region of Human OLIG2
Other Notes
Synthetic peptide located within the following region: AAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGF
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Delphine Pinatel et al.
eLife, 12 (2023-10-16)
The role of myelination for axonal conduction is well-established in projection neurons but little is known about its significance in GABAergic interneurons. Myelination is discontinuous along interneuron axons and the mechanisms controlling myelin patterning and segregation of ion channels at
Y Marie et al.
Lancet (London, England), 358(9278), 298-300 (2001-08-11)
OLIG2 is a recently identified transcription factor involved in the specification of cells in the oligodendroglial lineage. We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas
Qiao Zhou et al.
Cell, 109(1), 61-73 (2002-04-17)
OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest
Irene Bertolini et al.
EBioMedicine, 41, 225-235 (2019-02-10)
The V-ATPase proton pump controls acidification of intra and extra-cellular milieu in both physiological and pathological conditions. We previously showed that some V-ATPase subunits are enriched in glioma stem cells and in patients with poor survival. In this study, we
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