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Merck
CN

AV38735

Sigma-Aldrich

Anti-CITED2 (AB2) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, Anti-MRG1, Anti-P35SRJ

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

28 kDa

species reactivity

human, sheep, mouse, rat, pig, bovine, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_006070

UniProt accession no.

Q99967

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CITED2(10370)

Immunogen

Synthetic peptide directed towards the N terminal region of human CITED2

Biochem/physiol Actions

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (CITED2) is a transcriptional modulator that inhibits the transactivation of HIF1A-induced genes. It is required for the regulation of glycolysis in adult hematopoietic stem cells. Mutations and hypermethylation of CITED2 gene has been implicated in pediatric congenital heart disease. CITED2 acts as a molecular switch of TGF-α- and -β-induced cell growth.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: ADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNAL

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC9397

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Jinwei Du et al.
Stem cells and development, 23(2), 83-94 (2013-10-03)
Mammalian adult hematopoietic stem cells (HSCs) reside in the hypoxic bone marrow microenvironment and display a distinct metabolic phenotype compared with their progenitors. It has been proposed that HSCs generate energy mainly through anaerobic glycolysis in a pyruvate dehydrogenase kinase
Y-T Chou et al.
Cell death and differentiation, 19(12), 2015-2028 (2012-07-21)
Transforming growth factor-α (TGF-α)-induced proliferation and transforming growth factor-β (TGF-β)-mediated quiescence are intricately balanced in normal lung-tissue homeostasis but are deregulated during neoplastic progression of lung cancer. Here, we show that Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2), a
Zhan Yin et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10488-10493 (2002-08-01)
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300. Disruption of the gene encoding Cited2 is embryonic lethal because of defects in
Min Xu et al.
Journal of biomedical science, 21, 7-7 (2014-01-25)
The occurrence of Congenital Heart Disease (CHD) is resulted from either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is associated with the development of cardiac malformations. In this study, we have investigated the role

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