AV41392
Anti-TPM1 antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-CMH3, Anti-TMSA, Anti-TPM1-alpha, Anti-TropoMyosin 1 (α)
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About This Item
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
31 kDa
species reactivity
mouse, horse, guinea pig, sheep, canine, rat, zebrafish, rabbit, human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TPM1(7168)
General description
TropoMyosin 1 (α) (TPM1, CMH3, TMSA, TPM1) is an α-helical polypeptide involved in the stabilization of actin filament components of the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 in association with the troponin complex regulates calcium-dependent interaction of actin and myosin during muscle contraction. Defective TPM1 is associated with muscle diseases such as hypertrophic cardiomyopathy.
Immunogen
The immunogen for anti-TPM1 antibody: synthetic peptide derected towards the N terminal of human TPM1
Application
Anti-TPM1 polyclonal antibody is used to tag tropomyosin 1 (α) protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of tropomyosin 1 (α) in muscle contraction.
Biochem/physiol Actions
Anti-TPM1 polyclonal antibody reacts with zebrafish, human, mouse, rat, and canine tropomyosin 1-α proteins.
Physical form
Lyophilized from PBS buffer with 2% sucrose
Other Notes
Synthetic peptide located within the following region: DRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQE
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mian Wang et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(9), 2044-2053 (2011-08-06)
The goal of this study was to determine the expression signature and the potential role of microRNAs in human arteries with arteriosclerosis obliterans (ASO). The expression profiles of microRNAs in human arteries with ASO and in normal control arteries were
Carole L Moncman et al.
Experimental cell research, 319(3), 23-31 (2012-11-24)
Extraocular muscles are a unique subset of striated muscles. During postnatal development, the extraocular muscles undergo a number of myosin isoform transitions that occur between postnatal day P10 (P10) and P15. These include: (1) loss of embryonic myosin from the
Jin Wang et al.
Oncology reports, 33(3), 1326-1334 (2015-01-22)
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell