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Merck
CN

AV44721

Anti-LOC203547 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Hypothetical protein LOC203547, Anti-MGC125514, Anti-MGC125516, Anti-MGC131652

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

11 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001017980

UniProt accession no.

Q3ZAQ7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LOC203547(203547)

Immunogen

Synthetic peptide directed towards the N terminal region of human LOC203547

Application

Anti-LOC203547 antibody produced in rabbit is suitable for western blotting at a concentration of 5.0μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.

Biochem/physiol Actions

The protein encoded by LOC203547 is VMA21 vacuolar H+-ATPase homolog (VMA21), a chaperone for the assembly of lysosomal vacuolar ATPase, the major proton pump of cellular membrane in mammals. Mutations in VMA21 gene causes X-linked myopathy with excessive cell vacuolation, autophagy and tissue atrophy.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: MERPDKAALNALQPPEFRNESSLASTLKTLLFFTALMITVPIGLYFTTKS

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC14834

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Michio Hirano et al.
Cell, 137(2), 213-215 (2009-04-22)
The Vma21p protein in yeast is an essential assembly chaperone for the vacuolar ATPase, the major proton pump of cellular membranes. In this issue, Ramachandran et al. (2009) report that mutations in the gene encoding the human homolog VMA21 cause
Nivetha Ramachandran et al.
Acta neuropathologica, 125(3), 439-457 (2013-01-15)
X-linked Myopathy with Excessive Autophagy (XMEA) is a childhood onset disease characterized by progressive vacuolation and atrophy of skeletal muscle. We show that XMEA is caused by hypomorphic alleles of the VMA21 gene, that VMA21 is the diverged human ortholog

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