AV45633
Anti-NR1H2 (AB2) antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-LXR-b, Anti-LXRB, Anti-NER, Anti-NER-I, Anti-Nuclear receptor subfamily 1, group H, member 2, Anti-RIP15, Anti-UNR
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
51 kDa
species reactivity
mouse, horse, bovine, dog, rabbit, rat, human, guinea pig
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NR1H2(7376)
Immunogen
Synthetic peptide directed towards the middle region of human NR1H2
Application
Anti-NR1H2 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml.
Biochem/physiol Actions
Nuclear receptor subfamily 1, group H, member 2 (NR1H2), also known as liver X receptor β (LXRB), is a nuclear receptor that forms heterodimers with retinoid X receptors to regulate gene expression. The members of LXR family are involved in inflammation, macrophage activation and lipid metabolism. Polymorphisms in NR1H2 are associated with preeclampsia, atherosclerosis and Alzheimer′s disease.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: MIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAI
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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David H Volle et al.
Molecular and cellular endocrinology, 265-266, 183-189 (2007-01-09)
Various physiological functions have been ascribed to the liver X receptors (LXRs). Recently, we have identified new functions of these nuclear receptors in steroidogenic tissues. In adrenal, LXRalpha prevents accumulation of free cholesterol in mouse by controlling expression of genes
Mihir Parikh et al.
Journal of atherosclerosis and thrombosis, 21(6), 519-531 (2014-04-04)
The nuclear receptor liver X receptor [LXR] is activated by endogenous oxidized derivatives of cholesterol. It constitutes a critical receptor in the regulation of various physiological functions related to the development of metabolic and cardiovascular diseases, such as atherosclerosis and
Kevin Mouzat et al.
BMC medical genetics, 12, 145-145 (2011-10-28)
Preeclampsia is a frequent complication of pregnancy and a leading cause of perinatal mortality. Both genetic and environmental risk factors have been identified. Lipid metabolism, particularly cholesterol metabolism, is associated with this disease. Liver X receptors alpha (NR1H3, also known