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Merck
CN

AV46009

Anti-NCF4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Ncf4 Antibody, Ncf4 Antibody - Anti-NCF4 antibody produced in rabbit, Anti-MGC3810, Anti-NCF, Anti-Neutrophil cytosolic factor 4, 40 kDa, Anti-P40PHOX, Anti-SH3PXD4

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

39 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_038202

UniProt accession no.

Q15080

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NCF4(4689)

General description

The previously assigned protein identifier A8K4F9 has been merged into Q15080. Full details can be found on the UniProt database.

Immunogen

Synthetic peptide directed towards the N terminal region of human NCF4

Application

Anti-NCF4 antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/ml.

Biochem/physiol Actions

Anti-NCF4 antibody produced in rabbit is also referred as Anti-Neutrophil cytosolic factor 4, 40kDa, Anti-SH3PXD4 or Anti-P40PHOX.
P40PHOX is a cytosolic component of the activation complex NADPH oxidase that regulates membrane translocation of p67phox and p47phox through the PB1-PC interaction. It facilitates production of superoxide, a multicomponent enzyme system important for host defense. The Px domain of the protein interacts with lipid products of PI3K proposes its role in PI3 kinase-mediated signaling pathway.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: SKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQE

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC16126

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Futoshi Kuribayashi et al.
The EMBO journal, 21(23), 6312-6320 (2002-11-29)
Activation of the superoxide-producing phagocyte NADPH oxidase, crucial in host defense, requires the cytosolic proteins p67(phox) and p47(phox). They translocate to the membrane upon cell stimulation and activate flavocytochrome b(558), the membrane-integrated catalytic core of this enzyme system. The activators
F Kanai et al.
Nature cell biology, 3(7), 675-678 (2001-07-04)
PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to

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