AV54601
Anti-EPS15 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-AF-1P, Anti-AF1P, Anti-Epidermal growth factor receptor pathway substrate 15, Anti-MLLT5
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
99 kDa
species reactivity
human, rabbit, mouse, rat, horse, pig, bovine
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... EPS15(2060)
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General description
EPS15 gene encodes a protein, which is a tyrosine kinase substrate and is expressed ubiquitously. It is mapped to chromosome 1p31-p32 with three N-terminal conserved EH protein-protein interaction domains, a central coiled-coil region, and a C-terminal domain containing the AP-2 and AP-1 binding domains. The C-terminal domain also contains two ubiquitin interaction motifs (UIMs), required for Eps15 binding to ubiquitin.
Immunogen
Synthetic peptide directed towards the C terminal region of human EPS15
Application
Anti-EPS15 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
Biochem/physiol Actions
The encoded protein is an adaptor protein that plays a pivotal role in the clathrin mediated internalization and degradation of EGFR (epidermal growth factor receptor). It also regulates the endosomal trafficking of EGFR, possibly through the recruitment of the ubiquitinated receptors to the rims of clathrin-coated pits. Additionally, Dab2 recruits EPS15 protein and facilitates the internalization of integrin β1.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: LDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNF
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yaara Zwang et al.
Traffic (Copenhagen, Denmark), 10(4), 349-363 (2009-02-03)
Clathrin-mediated endocytosis sorts for degradation of more than 50 different growth factor receptors capable of relaying growth and differentiation signals by means of their cytoplasm-facing, intrinsic tyrosine kinase activity. The kinetics and alternative routings of receptor endocytosis critically regulate growth
W T Wong et al.
Oncogene, 9(6), 1591-1597 (1994-06-01)
Employing an expression cloning approach for tyrosine kinase substrates, we have previously isolated the coding sequence for a novel putative EGFR substrate, eps15, from NIH3T3 fibroblasts. Eps15 displayed a receptor-specific pattern of tyrosine phosphorylation in vivo and was able to
F Fazioli et al.
Molecular and cellular biology, 13(9), 5814-5828 (1993-09-01)
An expression cloning method which allows direct isolation of cDNAs encoding substrates for tyrosine kinases was applied to the study of the epidermal growth factor (EGF) receptor (EGFR) signaling pathway. A previously undescribed cDNA was isolated and designated eps15. The
Anjali Teckchandani et al.
Molecular biology of the cell, 23(15), 2905-2916 (2012-06-01)
Endocytic adaptor proteins facilitate cargo recruitment and clathrin-coated pit nucleation. The prototypical clathrin adaptor AP2 mediates cargo recruitment, maturation, and scission of the pit by binding cargo, clathrin, and accessory proteins, including the Eps-homology (EH) domain proteins Eps15 and intersectin.
Ingrid Roxrud et al.
The Journal of cell biology, 180(6), 1205-1218 (2008-03-26)
Down-regulation of activated and ubiquitinated growth factor (GF) receptors by endocytosis and subsequent lysosomal degradation ensures attenuation of GF signaling. The ubiquitin-binding adaptor protein Eps15 (epidermal growth factor receptor [EGFR] pathway substrate 15) functions in endocytosis of such receptors. Here
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