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Merck
CN

B012

6-Fluoronorepinephrine hydrochloride

solid

Synonym(s):

6-FNE

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About This Item

Empirical Formula (Hill Notation):
C8H10FNO3 · HCl
CAS Number:
70952-50-0
Molecular Weight:
223.63
UNSPSC Code:
12352200
PubChem Substance ID:
24277756
MDL number:
MFCD01529921

Key Documents

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Product Name

6-Fluoronorepinephrine hydrochloride, solid

InChI

1S/C8H10FNO3.ClH/c9-5-2-7(12)6(11)1-4(5)8(13)3-10;/h1-2,8,11-13H,3,10H2;1H

SMILES string

FC1=CC(O)=C(O)C=C1C(O)CN.[H]Cl

InChI key

QGDCLYPALFHCCD-UHFFFAOYSA-N

form

solid

color

off-white

solubility

H2O: soluble

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176)

Biochem/physiol Actions

α-adrenoceptor agonist.

Disclaimer

Photosensitive. Solutions slowly oxidize in light/oxygen in a manner comparable to norepinephrine hydrochloride.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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L M Stevens et al.
Developmental biology, 123(1), 179-190 (1987-09-01)
Previous studies suggest that the sympathetic innervation of the sweat glands in the rat is initially noradrenergic and during development undergoes a transition in neurotransmitter phenotype to become cholinergic. To characterize this system and its development further, we have examined
L Brasili et al.
European journal of pharmacology, 144(2), 141-146 (1987-12-01)
The effect of 6F-, 5F- and 2F-norepinephrine (6F-, 5F- and 2F-NE) in rat vas deferens, guinea-pig ileum and pithed rats was compared to that of norepinephrine (NE). The rank order of potency on postsynaptic alpha 1-adrenoreceptors, determined from the isometric
Eric A Stone et al.
The international journal of neuropsychopharmacology, 14(3), 319-331 (2010-05-13)
The present study examined the ability of 6-fluoronorepinephrine (6FNE), a full selective α-adrenoceptor agonist, to produce antidepressant-like effects in mice. The drug, administered in the 4th ventricle, produced marked anti-immobility effects at mid-dose range in the acute forced swim, tail
D Cantacuzene et al.
Science (New York, N.Y.), 204(4398), 1217-1219 (1979-06-15)
Substitution of fluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the alpha- and beta-adrenergic agonist properties of norephinephrine. The 6-fluoro isomer is an beta-adrenergic agonist with virtually no beta agonist activity
R C Ferry et al.
The Journal of biological chemistry, 269(50), 31850-31857 (1994-12-16)
Exposure of P11 cells to serotonin (5-HT) resulted in a transient increase in levels of 5-HT2A receptor mRNA. Exposure to 5-HT for as short a time as 1 min was sufficient to trigger a delayed increase in receptor mRNA. 5-HT-induced
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