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Merck
CN

B0152

Sigma-Aldrich

(−)-Bebeerine

~95% (TLC)

Synonym(s):

Aristolochine, Curine

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About This Item

Empirical Formula (Hill Notation):
C36H38N2O6
CAS Number:
Molecular Weight:
594.70
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
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Assay

~95% (TLC)

storage temp.

2-8°C

SMILES string

[H][C@@]12Cc3ccc(Oc4c(O)c(OC)cc5CCN(C)[C@]([H])(Cc6ccc(O)c(Oc7cc1c(CCN2C)cc7OC)c6)c45)cc3

InChI

1S/C36H38N2O6/c1-37-13-11-23-18-31(41-3)32-20-26(23)27(37)15-21-5-8-25(9-6-21)43-36-34-24(19-33(42-4)35(36)40)12-14-38(2)28(34)16-22-7-10-29(39)30(17-22)44-32/h5-10,17-20,27-28,39-40H,11-16H2,1-4H3/t27-,28-/m1/s1

InChI key

NGZXDRGWBULKFA-VSGBNLITSA-N

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Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Y Kondo et al.
International journal of immunopharmacology, 14(7), 1181-1186 (1992-10-01)
The bisbenzylisoquinoline (BBI) alkaloids, chondocurine, tetrandrine, isotetrandrine and cepharanthine, were tested for immunosuppressive activity in mice. A plaque-forming cell (PFC) response to a T-cell-dependent antigen, sheep red blood cell, was significantly suppressed by a 7 day treatment of chondocurine or
Aleksander Mendyk et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 41(3-4), 421-429 (2010-07-28)
The objective was to prepare neural models identifying relationships between formulation characteristics and pellet properties based on algorithmic approach of crucial variables selection and neuro-fuzzy systems application. The database consisted of information about 227 pellet formulations prepared by extrusion/spheronization method
Y Kondo et al.
Biochemical pharmacology, 46(11), 1887-1892 (1993-12-03)
Bisbenzylisoquinoline (BBI) alkaloids are anti-inflammatory constituents of plants of the families Menispermaceae and Ranunculaceae, which have been used as folk remedies in Japan and China. Five BBI alkaloids (cepharanthine, chondocurine, cycleanine, isotetrandrine and tetrandrine) were tested for suppressive effect on
Hidenori Naruoka et al.
Brain research. Developmental brain research, 143(2), 233-244 (2003-07-12)
Two independent in vitro regeneration systems of the embryonic chick retina (E4-5) were used to study the mobilisation of intracellular calcium by the neurotransmitters acetylcholine (ACh) and glutamate, as measured by Fura-2 fluorescence changes. Retinal pigment epithelium (RPE) explants under
V Castranova et al.
Toxicology and applied pharmacology, 108(2), 242-252 (1991-04-01)
The Chinese have conducted extensive studies concerning the medicinal properties of plant products. In this investigation the ability of three bisbenzylisoquinoline alkaloids to inhibit particle-induced activation of alveolar macrophages was evaluated and this inhibitory potential was correlated with the ability

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