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B1532

Resorufin benzyl ether

Name: Resorufin benzyl ether
Brand: SIGMA

CYP450 substrate, ≥98% (TLC), powder

Synonym(s):

7-Benzyloxy-3H-phenoxazin-3-one, 7-Benzyloxyresorufin, O⁷-Benzylresorufin

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₃NO₃

CAS Number:

87687-02-3

Molecular Weight:

303.31

UNSPSC Code:

12352204

PubChem Substance ID:

24891597

NACRES:

NA.32

MDL number:

MFCD00171613

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Product Name

Resorufin benzyl ether, CYP450 substrate

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

storage temp.

2-8°C

SMILES string

O=C1C=CC2=Nc3ccc(OCc4ccccc4)cc3OC2=C1

InChI

1S/C19H13NO3/c21-14-6-8-16-18(10-14)23-19-11-15(7-9-17(19)20-16)22-12-13-4-2-1-3-5-13/h1-11H,12H2

InChI key

XNZRYTITWLGTJS-UHFFFAOYSA-N

General description

Fluorimetric substrate for cytochrome P450-linked enzymes.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000300650

0000235437

0000229250

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Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels.

R Perrin et al.

Biochemical pharmacology, 40(9), 2145-2151 (1990-11-01)

The regional and subcellular distributions of rat brain cytochrome P450 and cytochrome P450-dependent activities were examined. Cytochrome P450 was found to be mainly localized in mitochondria in all the six cerebral regions studied. The activities of the isoforms mostly implicated

Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.

Y Q He et al.

Archives of biochemistry and biophysics, 335(1), 152-160 (1996-11-01)

Based on recent studies of single reciprocal mutants of cytochrome P450 2B4 and the highly related P450 2B5 at positions 114, 294, 363, and 367 [G. D. Szklarz, Y. Q. He, K. M. Kedzie, J. R. Halpert, and V. L.

Inhibition and induction of cytochrome P450 isoenzymes in rat lung.

R D Verschoyle et al.

The Journal of pharmacology and experimental therapeutics, 265(1), 386-391 (1993-04-01)

The O-dealkylation of pentoxyresorufin, a substrate for P450 2B1, was decreased in lung microsomes from rats dosed with O,O,S-trimethylphosphorodithioate, O,O,O-trimethylphosphorothioate, bromophos, fenitrothion, p-xylene and 2,4-dichloro-(6-phenylphonoxy)ethylamine. This activity was decreased by antibodies to P450 2B1 but unaffected by antibodies to P450

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy.

R R Meehan et al.

The Biochemical journal, 254(3), 789-797 (1988-09-15)

Cytochrome P-450s are a superfamily of haem-containing proteins involved in the metabolism of foreign compounds, as well as a variety of endogenous molecules. The hepatic levels and function of this diverse group of enzymes are determined by both constitutive and

Mechanism-based inhibition of mouse P4502b-10 by selected arylalkynes.

L E Beebe et al.

Biochemical pharmacology, 52(10), 1507-1513 (1996-11-22)

Suicide inhibitors of cytochrome P450 families are excellent tools to predict which isoforms mediate the metabolism/activation of a variety of chemical agents. We compared the inhibitory effects of several arylalkynes on mouse cytochromes P450 with published data for the rat

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Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

一期药物代谢

一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。

Global Trade Item Number

SKU	GTIN
B1532-10MG	04061833426173
B1532-5MG	04061833426180

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