Key Documents

View All Documentation

B1636

Pentagastrin

Name: Pentagastrin
Brand: SIGMA

≥95% (HPLC), powder, CCK2 receptor agonist

Synonym(s):

Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₃₇H₄₉N₇O₉S

CAS Number:

5534-95-2

Molecular Weight:

767.89

NACRES:

NA.77

PubChem Substance ID:

24891602

UNSPSC Code:

12352200

EC Number:

226-889-7

MDL number:

MFCD00076515

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

Storage condition:

(Keep container tightly closed in a dry and well-ventilated place.)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Pentagastrin, ≥95% (HPLC), powder

Quality Level

200

assay

≥95% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to off-white

solubility

DMF: 20 mg/mL, clear, colorless to faint yellow or tan

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O

InChI

1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)

InChI key

NEYNJQRKHLUJRU-UHFFFAOYSA-N

Gene Information

mouse ... Cckbr(12426)
rat ... Cckar(24889), Cckbr(25706)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecules

General description

Research area: Immunology & cytokines

Application

Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity. It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.

Biochem/physiol Actions

Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin. It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist. Pentagastrin stimulates the secretion of pepsin and gastric acid. It also aids in the evaluation of gastric acid secretory function. Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Radiopharmaceutical Formulation and Preclinical Testing of 68Ga-Labeled DOTA-MGS5 for the Regulatory Approval of a First Exploratory Clinical Trial.

Anton A Hörmann et al.

Pharmaceuticals (Basel, Switzerland), 14(6) (2021-07-03)

The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspects need to be considered to comply with the

Is basal ultrasensitive measurement of calcitonin capable of substituting for the pentagastrin-stimulation test?

Géraldine Pina et al.

Clinical endocrinology, 78(3), 358-364 (2012-08-24)

To evaluate a second-generation assay for basal serum calcitonin (CT) measurements compared with the pentagastrin-stimulation test for the diagnosis of inherited medullary thyroid carcinoma (MTC) and the follow-up of patients with MTC after surgery. Recent American Thyroid Association recommendations suggest

Functional, Diagnostic and Therapeutic Aspects of Gastrointestinal Hormones

Ahmed M and Ahmed S

Gastroenterology Research and Practice, 233-244 (2019)

Screening for medullary thyroid carcinoma with serum calcitonin measurements in patients with thyroid nodules in the United States and Canada.

Gilbert H Daniels

Thyroid : official journal of the American Thyroid Association, 21(11), 1199-1207 (2011-09-23)

Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy with the potential for aggressive behavior. Measurement of serum calcitonin (Ct) in the thyroid nodule population is the most sensitive way to detect occult MTC. An important and controversial question is

Pentagastrin as a stimulant in routine clinical testing of gastric acid secretion.

S A Pedersen

Digestion, 3(2), 81-89 (1970-01-01)

View All Related Papers

Global Trade Item Number

SKU	GTIN
B1636-100MG	04061832674551
B1636-25MG	04061833426265

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service