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B1636

Pentagastrin

Name: Pentagastrin
Brand: SIGMA

≥95% (HPLC), powder, CCK2 receptor agonist

Synonym(s):

Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide

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About This Item

Empirical Formula (Hill Notation):

C₃₇H₄₉N₇O₉S

CAS Number:

5534-95-2

Molecular Weight:

767.89

NACRES:

NA.77

PubChem Substance ID:

24891602

UNSPSC Code:

12352200

EC Number:

226-889-7

MDL number:

MFCD00076515

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

(Keep container tightly closed in a dry and well-ventilated place.)

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Properties

Product Name

Pentagastrin, ≥95% (HPLC), powder

Quality Segment

200

assay

≥95% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to off-white

solubility

DMF: 20 mg/mL, clear, colorless to faint yellow or tan

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O

InChI

1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)

InChI key

NEYNJQRKHLUJRU-UHFFFAOYSA-N

Gene Information

mouse ... Cckbr(12426)
rat ... Cckar(24889), Cckbr(25706)

Description

General description

Research area: Immunology & cytokines

Application

Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity. It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.

Biochem/physiol Actions

Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin. It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist. Pentagastrin stimulates the secretion of pepsin and gastric acid. It also aids in the evaluation of gastric acid secretory function. Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c