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Merck
CN

B1883

Benzidine

ISOPAC®, ≥98.0% (N)

Synonym(s):

4,4′-Diaminobiphenyl

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About This Item

Empirical Formula (Hill Notation):
C12H12N2
CAS Number:
92-87-5
Molecular Weight:
184.24
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
24891617
EC Number:
202-199-1
Beilstein/REAXYS Number:
742770
MDL number:
MFCD00039765

Key Documents

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Product Name

Benzidine, ISOPAC®, ≥98.0% (N)

InChI key

HFACYLZERDEVSX-UHFFFAOYSA-N

InChI

1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2

SMILES string

Nc1ccc(cc1)-c2ccc(N)cc2

assay

≥98.0% (N)

form

powder

Gene Information

human ... UGT1A4(54657)

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Biochem/physiol Actions

Tumor initiator in mammalian liver and urinary bladder.

Application

Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.

Disclaimer

OSHA′s Safety and Health Standard 29 CFR 1910 does not apply to a solution or mixture containing less than 0.1%. Injecting a compatible solvent permits preparation of any desired strength solution without exposure to benzidine.

Packaging

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Preparation Note

Dissolving the contents in 100 mL of solvent yields a 0.1% solution.

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLBF8865V
031M1184V
031M1184
018C00245
089K1039

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Hua Ling et al.
Biochemical and biophysical research communications, 401(4), 521-526 (2010-09-30)
Despite the significant role of S-ribosylhomocysteinase (LuxS) in the activated methyl cycle pathway and quorum sensing, the connectivity between luxS and other cellular functions remains incomplete. Herein, we show that luxS deletion significantly increases swimming motility and flagella synthesis in
Brian J Pak et al.
PLoS neglected tropical diseases, 8(8), e3002-e3002 (2014-08-08)
Strongyloidiasis is a persistent human parasitic infection caused by the intestinal nematode, Strongyloides stercoralis. The parasite has a world-wide distribution, particularly in tropical and subtropical regions with poor sanitary conditions. Since individuals with strongyloidiasis are typically asymptomatic, the infection can
G Choudhary
Chemosphere, 32(2), 267-291 (1996-01-01)
Benzidine, an odorless, white to slightly reddish-white crystalline organic compound, is an environmental contaminant that has been identified at about 30 National Priorities List (NPL) hazardous waste sites in the United States. In the environment, it is usually found attached
P D Josephy
Federation proceedings, 45(10), 2465-2470 (1986-09-01)
Benzidine oxidative activation may proceed by peroxidase-catalyzed one-electron oxidation via free radical intermediates, or by N-acetylation followed by monooxygenase-catalyzed N-hydroxylation. The peroxidase route has been examined by using horseradish peroxidase or prostaglandin H synthase in vitro. In the presence of
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 107-126 (1996-01-01)
The aromatic amine benzidine (BZ) has produced various tumors, including liver tumors, in mice, rats and hamsters. BZ forms DNA adducts in rodent liver, and it is positive in most genotoxicity tests. Only bladder tumors are produced in dogs and
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Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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