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Merck
CN

B2559

B581

>95% (HPLC), solid

Synonym(s):

N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C22H38N4O3S2
CAS Number:
149759-96-6
Molecular Weight:
470.69
NACRES:
NA.77
PubChem Substance ID:
24891659
UNSPSC Code:
12352202
MDL number:
MFCD00236999

Key Documents

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InChI key

QISLMXIYRQCLIR-FUMNGEBKSA-N

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O

InChI

1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1

assay

>95% (HPLC)

form

solid

composition

Peptide content, ~60%

color

white

solubility

H2O: soluble

storage temp.

−20°C

Gene Information

rat ... Fnta(25318)

Biochem/physiol Actions

Stable and membrane permeable inhibitor of farnesyltransferase.

Packaging

Packaged under nitrogen and with desiccant.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
065K4714
104K4701
092K4702

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A Wagle et al.
The Journal of biological chemistry, 273(24), 14968-14974 (1998-06-17)
Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis. Hepatic expression of G6PDH is known to respond to several dietary and hormonal factors
K Yoshimatsu et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 24(2), 145-155 (1997-01-01)
Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B1352, obtained from the screening of CAAX analog inhibitors of FTase, induced
S Unlu et al.
Journal of cardiovascular pharmacology, 35(2), 341-344 (2000-02-15)
The isoprenoids geranylgeraniol and farnesol are required for lipid modification of several important cellular proteins. In this study the effect of perillyl alcohol (PA), an inhibitor of geranylgeranyl transferase, was examined on proliferation and apoptosis of immortalized human vascular smooth
A M Garcia et al.
The Journal of biological chemistry, 268(25), 18415-18418 (1993-09-05)
The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, the first of which, farnesylation, is crucial for the function of the
Daniel Bakowski et al.
The Journal of physiology, 553(Pt 2), 387-393 (2003-11-05)
In many cell types, the emptying of intracellular Ca2+ stores results in the opening of store-operated Ca2+ channels in the plasma membrane. However, the nature of the signal that couples store content to the opening of these Ca2+ channels is
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