B3431
Bisindolylmaleimide V
≥98% (TLC), solid
Synonym(s):
1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045
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About This Item
Empirical Formula (Hill Notation):
C21H15N3O2
CAS Number:
Molecular Weight:
341.36
UNSPSC Code:
12352202
MDL number:
SMILES string
CN1C(=O)C(c2c[nH]c3ccccc23)=C(C1=O)c4c[nH]c5ccccc45
assay
≥98% (TLC)
form
solid
solubility
DMSO: soluble, methanol: soluble
storage temp.
−20°C
Application
Negative control for protein kinase C-inhibitory activity
Regulatory Information
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P D Davis et al.
Journal of medicinal chemistry, 35(1), 177-184 (1992-01-01)
The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described. These 2,3-bisarylmaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a. Optimum activity required the imide NH, both carbonyl
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