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B3685

Sigma-Aldrich

Monoclonal Anti-BOB78 antibody produced in mouse

clone BOB78, purified immunoglobulin, buffered aqueous solution

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About This Item

MDL number:
MFCD06798697
UNSPSC Code:
12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BOB78, monoclonal

form

buffered aqueous solution

mol wt

antigen ~90 kDa

species reactivity

mouse, human, monkey

concentration

~1 mg/mL

technique(s)

dot blot: suitable
flow cytometry: 1-2 μg/mL using 1x106 THP-1 cells treated with 3 μM camptothecin
immunocytochemistry: suitable
western blot: suitable

UniProt accession no.

Q9H251

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CDH23(64072)
mouse ... Cdh23(22295)

General description

The clearance of neutrophils that appear in large numbers at the inflammatory site is carried out by programmed cell death (apoptosis). An apoptotic neutrophil undergoes several changes in the amount of protein, carbohydrates and lipids. These changes are recognized by macrophages, which thus destroy the neutrophils by phagocytosis. BOB78, with a molecular mass of 90 kDa, is an up-regulated protein that appears in the granular compartment of the late apoptotic neutrophil. This protein does not appear in freshly isolated erythrocytes, platelets, lymphocytes, monocytes, or neutrophils.

Immunogen

serum-deprived THP-1 cells.

Application

Monoclonal Anti-BOB78 antibody produced in mouse is suitable for use in several immunochemical techniques such as immunoblotting, immunocytochemistry, dot-blot and flow cytometry. Monoclonal antibodies specific for BOB78 are useful for studying the biology of apoptotic neutrophils.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
064K4821

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