Skip to Content

Key Documents

View All Documentation

B3931

Bisindolylmaleimide X hydrochloride

≥90%, solid

Synonym(s):

Ro 31-8425

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C26H24N4O2 · HCl
CAS Number:
145317-11-9
Molecular Weight:
460.96
NACRES:
NA.77
PubChem Substance ID:
329773224
UNSPSC Code:
12352111
MDL number:
MFCD04972010
Assay:
≥90%
Form:
solid
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

synthetic (organic)

Quality Segment

200

assay

≥90%

form

solid

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16

InChI

1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H

InChI key

IMBOYWXMTUUYGZ-UHFFFAOYSA-N

Application

Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
  • in chemotaxis assays
  • to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
  • in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells

Biochem/physiol Actions

Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library