B3931
Bisindolylmaleimide X hydrochloride
≥90%, solid
Synonym(s):
Ro 31-8425
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About This Item
Empirical Formula (Hill Notation):
C26H24N4O2 · HCl
CAS Number:
Molecular Weight:
460.96
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥90%
form
solid
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI
1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI key
IMBOYWXMTUUYGZ-UHFFFAOYSA-N
Application
Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
- in chemotaxis assays
- to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
- in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells
Biochem/physiol Actions
Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Related Content
J E Merritt et al.
Cellular signalling, 9(1), 53-57 (1997-01-01)
Previous studies implicating a role for protein kinase C (PKC) in mediating stimulation of cellular responses by physiological agonists have relied on use of non-specific inhibitors or direct stimulation of PKC by phorbol esters. However, much of this evidence is
Jianjiang Ye et al.
Journal of virology, 84(23), 12405-12418 (2010-09-24)
The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced
André Strauss et al.
Protein expression and purification, 56(2), 167-176 (2007-08-28)
As exemplified by three cases, we show that the addition of a small molecular weight inhibitor to the culture of Baculovirus-infected insect cells can dramatically improve the expression of a recombinant kinase. The expression of the tyrosine kinase KDR was
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B3931-1MG | 04061826121573 |
| B3931-5MG | 04061832444574 |