B4309
Biocytinamide
Synonym(s):
Lys-(biotinyl)-NH2
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About This Item
Empirical Formula (Hill Notation):
C16H29N5O3S
CAS Number:
Molecular Weight:
371.50
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Form:
powder
InChI
1S/C16H29N5O3S/c17-10(15(18)23)5-3-4-8-19-13(22)7-2-1-6-12-14-11(9-25-12)20-16(24)21-14/h10-12,14H,1-9,17H2,(H2,18,23)(H,19,22)(H2,20,21,24)/t10-,11-,12-,14-/m0/s1
SMILES string
N[C@@H](CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(N)=O
InChI key
BFTIPPVTTJTHLM-MNXVOIDGSA-N
form
powder
storage temp.
−20°C
Application
Fluorogenic reagent for specific C-terminal labeling of peptides and proteins by carboxypeptidase Y catalyzed transpeptidation reactions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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H R Stennicke et al.
Analytical biochemistry, 248(1), 141-148 (1997-05-15)
The ability to carry out specific C-terminal modification or labeling of peptides and proteins has a broad range of applications. It is well established that this may be achieved by protease-catalyzed transacylation reactions and that carboxypeptidase Y (CPD-Y) is suitable
Wenwen Duan et al.
Proteomics, 16(1), 60-69 (2015-11-11)
Caspase activation and proteolytic cleavages are the major events in the early stage of apoptosis. Identification of protein substrates cleaved by caspases will reveal the occurrence of the early events in the apoptotic process and may provide potential drug targets
Stefan Dengl et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1763-1779 (2015-02-12)
Humanized hapten-binding IgGs were designed with an accessible cysteine close to their binding pockets, for specific covalent payload attachment. Individual analyses of known structures of digoxigenin (Dig)- and fluorescein (Fluo) binding antibodies and a new structure of a biotin (Biot)-binder
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