B4558
BW B70C
>98% (HPLC), solid
Synonym(s):
N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea
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About This Item
Empirical Formula (Hill Notation):
C17H17FN2O3
CAS Number:
Molecular Weight:
316.33
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
>98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble 22 mg/mL
storage temp.
2-8°C
SMILES string
CC(\C=C\c1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
InChI
1S/C17H17FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-12,22H,1H3,(H2,19,21)/b6-5+
InChI key
UAIYNMRLUHHRMF-AATRIKPKSA-N
Gene Information
human ... ALOX5AP(241)
Related Categories
Application
BW B70C has been used as a 5-lipoxygenase inhibitor to study its effects on eryptosis in erythrocytes.
Biochem/physiol Actions
BW B70C exhibits anti-inflammatory and anti-tumorigenic activities. It exhibits therapeutic effects against hepatocellular carcinoma. BW B70C plays a role in allergen-induced bronchoconstriction by reducing the allergic airway closure and glycoconjugate secretion.
Selective 5-lipoxygenase inhibitor.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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N J Lane et al.
Transplantation, 58(12), 1303-1308 (1994-12-27)
Compound BW B70C, a selective 5-lipoxygenase inhibitor was tested for its ability to reduce inflammatory damage in an in vivo rabbit model of renal storage and transplantation. Kidneys were stored at 0-2 degrees C for 48 hr prior to autografting.
B Dugas
Allergie et immunologie, 32(7), 284-289 (2000-11-30)
The effect of Lyprinol was evaluated on LTB4-induced human monocytes (normal and allergic donors) activation. Peripheral blood normal monocyte-derived monocytes when stimulated by Interleukin-4 (IL-4) produced high amounts of leukotriene B4 (LTB4) through the activation of the 5-lipoxygenase pathway. Maximal
M F Bureau et al.
European journal of pharmacology, 324(1), 89-98 (1997-04-11)
The interference of the 5-lipoxygenase inhibitor, BW B70C ((E)-N-(3-[3-(4-fluorophenoxy)phenyl]-1(R,S)-methyl prop-2-enyl)-N-hydroxyurea), with Escherichia coli lipopolysaccharide (endotoxin)-induced lung leucocyte sequestration and microvascular albumin exchanges was evaluated in the anaesthetised guinea-pig using radioactive tracers, in parallel to the effects on cell counts in
T J Morley et al.
Toxicology and applied pharmacology, 146(2), 299-308 (1997-11-05)
In a study of structure-activity relationship with drug-induced nephropathy two lipoxygenase inhibitors, the N-hydroxyurea derivative 70C ((E)-N-{3-[3-(4-fluorophenoxy) phenyl]-1-(R, S)-methylprop-2-enyl}-N-hydroxyurea) and the N-hydroxamic acid analogue 360C ((E)-N-{3-[3-(4-fluorophenoxy) phenyl]-1-(R, S)-methylprop-2-enyl}-N-hydroxamic acid), were administered to rats. 70C and 360C were dosed to female
M Yeadon et al.
Pulmonary pharmacology, 8(1), 53-63 (1995-02-01)
A method has been established for measurement of tracheal secretions in anaesthetized, ventilated guinea-pigs. The upper trachea was cannulated and perfused with saline. The perfusate was analysed for protein using the Lowry assay and for glycoconjugates ('mucus') by a procedure
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