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Merck
CN

B6556

Sigma-Aldrich

BCMA/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder

Synonym(s):

B cell maturation

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About This Item

MDL number:
MFCD03456173
UNSPSC Code:
51111800

Key Documents

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biological source

human

recombinant

expressed in HEK 293 cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

~40 kDa by SDS-PAGE (reducing)

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

solubility

water: soluble

UniProt accession no.

Q02223

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TNFRSF17(608)

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Biochem/physiol Actions

BCMA, a member of the TNF receptor superfamily, binds to the TNF ligands, APRIL and BAFF. It stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.
Member of the TNF receptor superfamily; binds to the TNF ligands, APRIL and BAFF; stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.
The extracellular domain (amino acids 2-54) of human BCMA is fused to the Fc portion of human IgG.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

Inhibits BAFF- and April-mediated B cell activation. May be used to detect cell surface BAFF by flow cytometry.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
061K1419

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