B7670
Benzetimide hydrochloride
~97% (TLC), powder
Synonym(s):
3-Phenyl-1′-phenylmethyl-[3,4′-bipiperidine]-2,6-dione, R4929
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About This Item
Empirical Formula (Hill Notation):
C23H26N2O2 · HCl
CAS Number:
Molecular Weight:
398.93
UNSPSC Code:
12352204
EC Number:
227-072-8
MDL number:
assay
~97% (TLC)
form
powder
color
off-white
solubility
H2O: 6.25 mg/mL
Biochem/physiol Actions
Muscarinic acetylcholine receptor antagonist. Dexetimide is the active enantiomer of this racemic mixture.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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W M Blankesteijn et al.
European journal of pharmacology, 244(1), 21-27 (1993-01-04)
Muscarinic receptors in mammalian kidney seem to be involved in diuresis. In this study we give a detailed characterization of receptors in rat kidney. Specific binding of [3H](-)-quinuclidinylbenzilate ([3H]QNB) to membranes of rat kidney cortex was saturable and of high
D L DeHaven-Hudkins et al.
Life sciences, 53(1), 41-48 (1993-01-01)
The allosteric modulation of sigma recognition sites by phenytoin (diphenylhydantoin) has been demonstrated by the ability of phenytoin to stimulate binding of various [3H] sigma ligands, as well as to slow dissociation from sigma sites and to shift sigma sites
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