Selectively opening the blood-tumour barrier (BTB) is critical to deliver antitumour drugs from blood to tumour tissues. The BTB problem is attributed to the tight junctions (TJs), which consist of several transmembrane proteins. To investigate whether borneol could open the

In vivo effect of borneol on rat hepatic CYP2B expression and activity.

Jing-Ya Chen et al.

Chemico-biological interactions, 261, 96-102 (2016-11-28)

CYP2B subfamily accounts for 2-10% of total hepatic CYP450 enzymes and participate in the metabolism of around 8% of clinical drugs. Borneol has been widely used in traditional Chinese medicine for thousands of years. There are many studies about borneol-induced

Bioavailability and brain-targeting of geniposide in gardenia-borneol co-compound by different administration routes in mice.

Yang Lu et al.

International journal of molecular sciences, 13(11), 14127-14135 (2012-12-04)

Both geniposide (Ge) and borneol (Bo) are bioactive substances derived from traditional Chinese medicine. Injections containing co-compound of Gardenia-Borneol are widely used for stroke treatment in China, such as "Xingnaojing" multi-component injection. As more and more adverse reactions (especially drug

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