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Merck
CN

B7935

Sigma-Aldrich

Anti-BACE-2, N-terminus (43-60) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Asp1, Anti-DRAP (Down region aspartic protease), Anti-Memapsin 1

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About This Item

MDL number:
MFCD07370266
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect immunofluorescence: 2-4 μg/mL using HEK293 cells transfected with human BACE-2
western blot: 0.5-1 μg/mL using whole extract of human HEK293 cells transfected with human BACE-2

UniProt accession no.

Q9Y5Z0

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... BACE2(25825)

Immunogen

synthetic peptide corresponding to amino acids 43-60 near the N-terminus of human BACE-2.

Biochem/physiol Actions

The immunogen sequence is specific for BACE-2 and is not found in BACE-1 homolog.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
114K4833
124K4833

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B D Bennett et al.
The Journal of biological chemistry, 275(27), 20647-20651 (2000-04-06)
Beta-site amyloid precursor protein cleaving enzyme (BACE) is a novel transmembrane aspartic protease that possesses all the known characteristics of the beta-secretase involved in Alzheimer's disease (Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P.
Guriqbal Basi et al.
The Journal of biological chemistry, 278(34), 31512-31520 (2003-06-13)
The deposition of extracellular beta-amyloid peptide (A beta) in the brain is a pathologic feature of Alzheimer's disease. The beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), an integral membrane aspartyl protease responsible for cleavage of amyloid precursor protein (APP)

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