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Merck
CN

B8061

N-Butyl-N-(4-hydroxybutyl)nitrosamine

ISOPAC®, ≥90% (GC)

Synonym(s):

BBN, N-Butyl-N-butan-4-ol-nitrosamine, N-Butyl-N-nitroso-4-aminobutanol, OH-BBN

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About This Item

Empirical Formula (Hill Notation):
C8H18N2O2
CAS Number:
3817-11-6
Molecular Weight:
174.24
MDL number:
MFCD00059008
UNSPSC Code:
12352116
NACRES:
NA.25

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Product Name

N-Butyl-N-(4-hydroxybutyl)nitrosamine, ISOPAC®, ≥90% (GC)

SMILES string

N(N=O)(CCCCO)CCCC

InChI

1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3

InChI key

DIKPQFXYECAYPC-UHFFFAOYSA-N

assay

≥90% (GC)

form

liquid

storage temp.

2-8°C

Quality Level

200

Biochem/physiol Actions

Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.

Disclaimer

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Packaging

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Preparation Note

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

296.6 °F

flash_point_c

147 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000517878
0000517878
0000503918
0000503878
0000503918

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Yuji Sagara et al.
Cancer epidemiology, 34(3), 350-354 (2010-04-07)
Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given
João C Fernandes et al.
Marine drugs, 10(12), 2661-2675 (2013-01-25)
Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange
Vernon E Steele et al.
Cancer prevention research (Philadelphia, Pa.), 2(11), 951-956 (2009-11-07)
Nonsteroidal anti-inflammatory drugs (NSAID) have been highly effective in preventing colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon adenoma formation. However, certain NSAIDs cause gastrointestinal ulceration and may increase cardiovascular events. Naproxen seems to
Ting-Tsz Ou et al.
Journal of ethnopharmacology, 135(1), 162-172 (2011-03-15)
Extracts of Paeonia lactiflora Pall (RPA), a traditional Chinese medicines has been shown to treat cancers. The purpose of this study is to evaluate the anticancer effect of RPA in urinary bladder carcinoma in vitro and in vivo. The cell
Nelci Antunes de Moura et al.
Archives of toxicology, 84(2), 165-173 (2009-11-11)
The potential promoting effect of Diuron was investigated in a mouse model of mammary and urinary bladder carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Four-week old female Swiss mice were allocated to five groups: Groups G1-G3 received DMBA (5
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