B8252
Bromonucleic acid
Synonym(s):
2-Bromostearic Acid
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About This Item
PubChem Substance ID:
UNSPSC Code:
41106305
extent of labeling
~6% Br (by weight)
storage temp.
−20°C
Application
2-Bromostearate acid (bromonucleic acid) is used to inhibit fatty acid oxidation. 2-Bromostearate acid is a mitochondrial carnitine palmitoyltransferase I (CPT I) inhibitor.
Preparation Note
Bromination of yeast RNA.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C R Bliss et al.
The American journal of physiology, 263(5 Pt 1), E890-E896 (1992-11-01)
The development of glucose-stimulated insulin release and time-dependent potentiation (TDP) has been studied in isolated islets from 7-, 14-, and 21-day-old and 3-mo-old rats. Responses were small at 7 days and changed little at 14 days. At 21 days the
Effect of 2-bromostearate on glucose-phosphorylating activities and the dynamics of insulin secretion in islets of Langerhans during fasting.
Bedoya FJ, Ramirez R, Arilla E, Goberna R.
Diabetes, 33, 858-863 (1084)
S Chen et al.
Diabetes, 43(7), 878-883 (1994-07-01)
We sought to explore the emerging concept that malonyl-CoA generation, with concomitant suppression of mitochondrial carnitine palmitoyltransferase I (CPT I), represents an important component of glucose-stimulated insulin secretion (GSIS) by the pancreatic beta-cell (Prentki M, Vischer S, Glennon MC, Regazzi
J Tamarit-Rodriguez et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 16(3), 115-119 (1984-03-01)
The hypothesis was made of an increased oxidation of fatty acids (FFA) and a decrease of their esterification rate contributing to the islet secretory defect during starvation. 2-Bromostearate (BrS), a FFA-oxidation inhibitor, was therefore tested on the islet secretion of
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