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B8435

BiCAPPA

Name: BiCAPPA
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

N,N′-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine

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About This Item

Empirical Formula (Hill Notation):

C₃₈H₄₀Cl₂N₆O₂

CAS Number:

119662-55-4

Molecular Weight:

683.67

NACRES:

NA.77

PubChem Substance ID:

24724426

UNSPSC Code:

12352202

MDL number:

MFCD07370130

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

under inert gas

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assay

≥97% (HPLC)

form

solid

storage condition

under inert gas

color

yellow

solubility

DMSO: ~10 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc2nc3cc(Cl)ccc3c(NCCCN4CCN(CCCNc5c6ccc(Cl)cc6nc7ccc(OC)cc57)CC4)c2c1

InChI

1S/C38H40Cl2N6O2/c1-47-27-7-11-33-31(23-27)37(29-9-5-25(39)21-35(29)43-33)41-13-3-15-45-17-19-46(20-18-45)16-4-14-42-38-30-10-6-26(40)22-36(30)44-34-12-8-28(48-2)24-32(34)38/h5-12,21-24H,3-4,13-20H2,1-2H3,(H,41,43)(H,42,44)

InChI key

GUTKNTSGEOMFPZ-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of the formation of abnormal β-rich isoform of prion protein PrP^Sc.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

114K4617

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Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Barnaby C H May et al.

Proceedings of the National Academy of Sciences of the United States of America, 100(6), 3416-3421 (2003-03-11)

Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency

Protein aggregation and neurodegenerative disease.

Christopher A Ross et al.

Nature medicine, 10 Suppl, S10-S17 (2004-07-24)

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates

Global Trade Item Number

SKU	GTIN
B8435-5MG	04061832977119

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