B8436
Anti-Brachyury antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-T, Anti-T Brachyury, mouse homolog, Anti-T brachyury-like, Anti-TFT, Anti-Transcription factor T
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:250, western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Brachyury (T) is an oncogene mapped to human chromosome 6q27. This gene codes for Brachyury, which is expressed throughout the primary mesoderm during the early stages of embryogenesis. Brachyury protein structure comprises highly conserved DNA binding domain, known as T-box domain.
Immunogen
synthetic peptide corresponding to an internal sequence of human brachyury (GeneID 6862). This sequence is 80% identical in mouse and 86% identical in rat.
Biochem/physiol Actions
Brachyury protein is a transcription factor that aids in the embryonic development of notochord tissue. It also plays an essential role in posterior mesoderm formation and differentiation. Brachyury is highly expressed in a variety of cancers including, chordoma and hemangioblastoma. It serves as an immunohistochemical marker for differential diagnosis of chordoma and hemangioblastoma (HBL).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Scott W Connors et al.
F1000Research, 9 (2020-07-30)
Chordomas are rare and difficult-to-treat tumors arising from the embryonic notochord. While surgery is the mainstay of treatment, and despite new techniques aimed at maximizing total tumoral resection, recurrence remains high and the probability of disease-free survival low. New breakthroughs
Ashley E E Bruce et al.
Mechanisms of development, 163, 103625-103625 (2020-06-12)
The Brachyury gene encodes a transcription factor that is conserved across all animals. In non-chordate metazoans, brachyury is primarily expressed in ectoderm regions that are added to the endodermal gut during development, and often form a ring around the site
Jianjian Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3820-3825 (2016-03-24)
The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B8436-100UG | 04061837768279 |