B8810
BAY 41-2272
≥97% (HPLC)
Synonym(s):
3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine
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About This Item
Empirical Formula (Hill Notation):
C20H17FN6
CAS Number:
Molecular Weight:
360.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to light brown
mp
210.5-211.4 °C
solubility
DMSO: 5 mg/mL, clear (warmed)
originator
Bayer
storage temp.
2-8°C
SMILES string
Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
InChI
1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChI key
ATOAHNRJAXSBOR-UHFFFAOYSA-N
Application
BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons.
Biochem/physiol Actions
BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance.
BAY 41-2272 is an activator of soluble guanylate cyclase; stimulates sGC through a non-NO mechanism; inhibits platelet aggregation, and induces vasorelaxation without nitrate tolerance.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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